
Risk of ruin is the probability that a run of losses takes your account down to a level you cannot accept, such as a prop firm's maximum drawdown.
A strategy winning 45% of trades with 2R winners rarely hits a 20% drawdown over 300 trades at 1% risk, but becomes far more likely to at 3% risk.
Run simulations with the risk of ruin calculator. Related: position sizing, Kelly criterion, drawdown. See the trading glossary.